NY 104, former US 104 and NY 126, starts in Niagara Falls and extends past I-81. The freeway in Rochester serves as a bypass of Ridge Road east of the Genesee River and a connector to Webster. The portion west of NY 590, known as the Keeler Street Expressway, is also a part of Rochester's "Outer Loop". East of Webster, it becomes a divided highway and is a major corridor to Oswego. The last portion of the freeway constructed was between Five Mile Line Road and NY 250, with traffic following the frontage road for many years. The old alignment followed Ridge Road (which used to connect to the Veterans Memorial Bridge via a traffic circle), Culver Road, and NY 404. In the 2000s, the freeway was extended west from the Veterans Bridge to Ridgeway Ave after the adjacent houses burned down in a fire.
| Actual Mile Posted Mile |
Eastbound | Westbound | Notes |
|---|---|---|---|
| Monroe County | |||
| Speed Limit 35 | |||
| 81.8 N/A |
 |
 Ridgeway Avenue Lake Avenue Freeway Ends |
|
| 82.0 N/A |
Maplewood Drive | ||
| Speed Limit 55 | Speed Limit 35 | ||
| 82.3 0.0 |
East Ridge Road St. Paul Street |
||
| 82.6 0.3 |
Clinton Avenue Seneca Avenue |
||
| 82.8 0.5 |
Seneca Avenue Clinton Avenue |
||
| 83.3 1.0 |
Hudson Avenue | ||
| 83.7 1.4 |
Carter Street Portland Avenue |
Carter Street Hudson Avenue |
|
| 84.5 2.2 |
Goodman Street | Goodman Street Portland Avenue |
|
| 85.2 2.9 |
Culver Road Sea Breeze |
||
| 86.0 3.7 |
 SouthDowntown Rochester |
No access to NY 590 north. Stubs at mile 4.9 for ramps from NY 590 south to NY 104 east and NY 104 west to NY 590 north |
|
| 88.3 6.0 |
Bay Road | ||
| 90.3 8.0 |
Five Mile Line Road | ||
| 91.0 8.7 |
Hard Road | ||
| 91.7 9.4 |
Holt Road | Hold Road Hard Road |
|
| 92.6 10.3 |
 Webster |
||
| 93.2 10.9 |
Phillips Road | ||
| 94.1 11.8 |
Salt Road | Salt Road Xerox Area |
|
| 94.8 12.5 |
Basket Road Freeway Ends |
|
|
| Speed Limit 55 | |||
| Monroe County | |||