NY 12 has a freeway segment in and near Utica and forms Utica's north-south arterial. North of Utica, the divided highway continues through Remsento Alder Creek. The route is a major highway, connecting Binghamton to Utica and Utica to Lowville, Watertown, and the Thousand Islands. NY 12 has no milemarkers; this list counts from the route beginning near Binghamton.
| Mile | Northbound | Southbound | Notes |
|---|---|---|---|
| Oneida County | |||
| Speed Limit 55 | |||
| 79.9 |   |
  West  SouthSyracuse Clinton Freeway Ends |
|
| 80.3 | Wilbur Road | ||
| Railroad Crossing | |||
 |
 |
||
| 80.6 |  SouthNew Hartford |
||
| 80.6 |  WestWhitestown |
||
| 80.9 | Lomond Place | Lomond Place To Chenango Road To New Hartford Street |
|
| 81.6 | French Road | ||
| 82.3 | Burrstone Road Lincoln Avenue |
Burrstone Road New York Mills |
|
| Speed Limit 40 | Speed Limit 55 | ||
| 82.9 | Oswego Street | At-grade intersection | |
| 83.1 | Noyes Street | At-grade intersection | |
| Speed Limit 55 | Speed Limit 40 | ||
| 83.7 | Court Street | Court Street Arts District Brewery District |
|
 |
 |
||
| 84.0 |   Oriskany Street Whitesboro |
West East Whitesboro Downtown Utica |
|
| 85.2 | To  To   East East  WestRome Herkimer |
To To East East Herkimer |
|
| |
 |
||
| 85.2 | West Rome |
||
| 85.3 | River Road | ||
| 85.5 | Shopping Center | ||
| 86.0 | To Mulaney Road Horatio Street |
||
| 86.7 | Horatio Street Seymour Road |
||
| 87.1 | Trenton Road Glass Factory Road Holland Patent |
  |
|
| 89.9 | North Poland Speculator |
North |
|
|
|
||
| 93.4 | Putnam Road South Trenton |
|
|
| 94.1 | Freeway Ends |
|
|
| Speed Limit 55 | |||
| Oneida County | |||