The NY 198 corridor was originally served by Scajaqueda Drive and Humboldt Parkway, which were two surface streets through Delaware Park. They were upgraded to a freeway known as the Scajaqueda Expressway (NY 198) in the 1960s, connecting NY 33 to I-190. Resident opposition to the expressway has always been high, and a fatal accident in 2015 resulted in a speed limit reduction from 50 to 30, a restriping of the road to narrow lanes and eliminate acceleration/deceleration lanes, and install guiderail. The accident also caused the movement to remove the freeway to rise into prominence and become very politically influential with both Buffalo and the state.
| Mile | Eastbound | Westbound | Notes |
|---|---|---|---|
| Erie County | |||
| Speed Limit 30 | |||
| 0.0 |  |
 SouthDowntown |
|
| 0.0 | North Niagara Falls |
||
| 0.1 |   |
||
| 0.8 | Grant Street Buffalo State College |
||
| 1.5 | Elmwood Avenue South Art Gallery |
||
| 1.5 | Elmwood Avenue Art Gallery History Museum |
Elmwood Avenue North History Museum |
|
| 2.1 |  SouthDelaware Avenue |
Delaware Avenue |
|
| 2.1 | North Delaware Avenue |
||
| 2.7 | Parkside Avenue | Parkside Avenue Buffalo Zoo |
At-grade intersection Former traffic circle |
| 3.0 |  Main Street No commercial vehicles |
||
| 3.5 |  EastAirport |
||
| 3.5 | West Downtown |
 |
|
| Speed Limit 30 | |||
| Erie County | |||