NY 5S has a freeway segment extending from Utica to Mohawk; this forms Utica's east-west arterial. The majority of the freeway was built in the early 1970s; a two lane extenstion bypassing Ilion was built in the 80s. The speed limit is only 55 as bicyclists can legally use the highway.
| Mile | Eastbound | Westbound | Notes |
|---|---|---|---|
| Oneida County | |||
| Speed Limit 55 | |||
| 1.1 |  |
 Broad Street Freeway Ends |
|
| 2.5 | Culver Avenue | To Broad Street Culver Avenue |
|
| 3.0 | Turner Street | Right-in, right-out only | |
| Herkimer County | Oneida County | ||
| 4.1 | Dyke Road West Schuyler |
  |
|
| 9.3 | Frankfort Fair Grounds |
Frankfort Cemetary Street Fair Grounds |
 To  |
| 11.6 | Ilion West Main Street |
Frankfort Main Street |
Begin two-lane undivided freeway (super-2) |
| 12.7 |  Ilion |
To  |
|
| 14.3 |   SouthFreeway Ends |
|
|
| Speed Limit 55 | |||
| Herkimer County | |||