Interstate 88 is a rural freeway running from Binghamton to Albany. It was not part of the original interstate system but was added in 1968. It was planned to connect to I-90 and I-890 at Thruway exit 25 and then continue east along an upgraded NY 7 to Troy. It was later realigned to meet the Thruway to the west, and the upgraded NY 7 (aside from the portion between I-87 and I-787) was cancelled, with the Thruway widened instead. As a result, tolls are not collected to/from I-88 for I-890 or I-90/I-87 (exits 26, 25, and 24). There was also a proposal, never implemented, to extend I-88 along the free portion of I-90 through Albany and route I-90 over the Castleton-on-Hudson Bridge.
| Mile | Eastbound | Westbound | Notes |
|---|---|---|---|
| Broome County | |||
| Speed Limit 55 | |||
| 0.0 |  |
 South To  To  Binghamton |
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| 0.0 | North Syracuse |
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| 0.3 | Exit 1 WestBinghamton |
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| 2.1 | Exit 2 WestChenango Bridge |
Exit 2 West To  Chenango Bridge |
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| 4.3 | Exit 3 Port Crane |
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| Speed Limit 65 | Speed Limit 55 | ||
| 7.7 | Exit 4 East Sanitaria Springs |
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| 11.7 | Exit 5 Martin Hill Road Belden |
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| 15.7 | Exit 6 Harpursville Nineveh |
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| Chenango County | Broome County | ||
| 23.5 | Exit 7 Afton |
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| 29.2 | Exit 8 Bainbridge Masonville |
Exit 8 Bainbridge |
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| Delaware County | Chenango County | ||
| 32.7 | Exit 9 Sidney |
Exit 9 Sidney Masonville |
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| 37.7 | Exit 10 Unadilla |
The exit ramp is a mile long four lane divided highway, including an intermediate intersection | |
| Ostego County | Delaware County | ||
| Delaware County | Ostego County | ||
| 39.5 | Unadilla Rest Area Text Stop Truck Inspection |
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| 40.3 | Exit 11 Unadilla Franklin |
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| 42.4 | Wells Bridge Rest Area Text Stop Truck Inspection |
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| Ostego County | Delaware County | ||
| 46.6 | Exit 12 Otego Wells Bridge |
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| 53.3 | Exit 13 To  WestOneonta Morris |
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| 55.5 | Exit 14 SouthMain Street No re-entry |
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| 56.2 | Exit 15 Oneonta Davenport |
Exit 15 South Oneonta Davenport |
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| 58.4 | Exit 16 Emmons West Davenport |
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| 61.2 | Exit 17 To NorthColliersville Cooperstown |
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| 70.3 | Exit 18 Schenevus |
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| 70.8 | Exit 18 Schenevus |
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| 73.6 | Worcester Rest Area Text Stop Truck Inspection |
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| 76.3 | Exit 19 To Worcester East Worcester |
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| 78.9 | East Worcester Rest Area Text Stop Truck Inspection |
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| Schoharie County | Ostego County | ||
| 87.7 | Exit 20  Richmondville |
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| 89.8 | Exit 21 Warnerville Cobleskill |
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| 94.9 | Exit 22  Cobleskill Middleburgh |
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| 100.8 | Exit 23   Schoharie Central Bridge |
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| Schenectady County | Schoharie County | ||
| 111.9 | Exit 24 Duanesburg |
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| 116.6 | Exit 25 Rotterdam Schenectady Last exit before toll |
Exit 25 Rotterdam Schenectady |
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| 117.0 | Tandem Lot | Westbound access via exit 25 | |
| 117.3 | Left Exits 26-61  West TollBuffalo |
 West TollNo toll to/from Thruway exit 26 |
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| 117.3 | Exits 25-1 East Toll Albany |
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East Toll To  No toll to/from Thruway exits 25 and 24 |
| Speed Limit 65 | |||
| Schenectady County | |||