Business Loop 81 is the designation for former I-81 through downtown Syracuse. In 2024, construction began on a series of projects to move I-81 onto former I-481 around Syracuse in order to facilitate the removal of the viaduct carrying I-81 through downtown. The designation is the first interstate business loop in New York.
| Mile | Northbound | Southbound | Notes |
|---|---|---|---|
| Onondaga County | |||
| Speed Limit 55 | |||
| 0.0 | Binghamton |
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| 0.0 | Left Exit 1A Watertown |
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| 0.3 | Exit 1A East Glen Avenue Brighton Avenue |
Exit 1B East Glen Avenue Brighton Avenue |
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| 0.9 | Exit 1B South Salina Street Brighton Avenue |
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| 1.2 | Exit 1C South State Street South Salina Street Brighton Avenue |
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| Speed Limit 55 | |||
| 2.8 | Exit 18 Adams Street Harrison Street |
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| Speed Limit 45 | |||
| 3.2 | East Syracuse |
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| 3.5 | Fairgrounds Baldwinsville |
East Syracuse |
|
| 3.9 | Exit 19 Clinton Street Salina Street |
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| Speed Limit 55 | Speed Limit 45 | ||
| 4.0 | Exit 20 Franklin Street West Street |
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| 4.4 | Exit 21 Catawba Street Spencer Street |
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| 4.7 | Exit 22 Court Street |
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| 5.4 | Exits 23-24A-24B Park Street Liverpool Exit 24A (NY 370 West - Onondaga Lake Parkway) closed |
Hiawatha Boulvevard Old Liverpool Road Onondaga Lake Parkway Central New York Welcome Center |
|
| 6.1 | Exits 5B-5A-4B Hiawatha Boulevard Destiny USA Drive Bear Street |
Central New York Welcome Center | |
| Speed Limit 65 | Speed Limit 55 | ||
| 6.8 | Exit 6 7th North Street |
Exit 6 7th North Street Liverpool |
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| 7.2 | Exit 7 Albany Buffalo |
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| 8.5 | Exit 8 Mattydale |
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| 9.2 | Exits 9A-B Syracuse Airport Taft Road North Syracuse |
Exits 9A-8 Syracuse Airport Mattydale |
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| 10.0 | Exit 9B Taft Road North Syracuse |
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| 11.4 | Exit 11A Binghamton |
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| 11.4 | Exit 11B Oswego |
Exit 11 Oswego |
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| 11.8 | Watertown |
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| Speed Limit 65 | |||
| Onondaga County | |||