NY 378 is a short touring route connecting US 9 in Colonie with US 4 in Troy. It originally followed Menand Road from US 9 to NY 32. It was realigned in the 1950s to follow the new highway connecting US 9 to the Troy-Menands Bridge (then numbered as part of NY 2). When NY 2 was truncated to US 4 in Troy in 1978, the bridge and road connecting to US 4 became an extension of NY 378.
| Mile | Eastbound | Westbound | Notes |
|---|---|---|---|
| Albany County | |||
| Speed Limit 55 | Speed Limit 45 | ||
| 1.4 |  |
 Freeway ends |
|
| 1.9 |  SouthMenands |
||
| 1.9 | North Watervliet |
Watervliet Menands |
|
| 2.5 |  SouthAlbany |
Left South Albany |
|
| 2.5 | North Cohoes |
||
| 2.7 | Freeway ends |
|
|
| Speed Limit 30 | Speed Limit 55 | ||
| Albany County | |||