NY 5S has a freeway segment extending from Utica to Mohawk; this forms Utica's East-West Arterial. The majority of the freeway was built in the early 1970s; a two lane extenstion bypassing Ilion was built in the 80s. The speed limit is only 55 as bicyclists can legally use the highway.
| Mile | Eastbound | Westbound | Notes |
|---|---|---|---|
| Oneida County | |||
| Speed Limit 55 | |||
| 1.1 |  |
 Broad Street |
At-grade intersection |
| 2.5 | Culver Avenue | To Broad Street Culver Avenue |
|
| 3.0 | Turner Street | ||
| Herkimer County | Oneida County | ||
| 4.1 | Dyke Road West Schuyler |
  |
|
| 4.4 | To Dyke Road West Schuyler |
|
|
| 9.3 | Higby Road Frankfort |
Cemetary Street Frankfort |
 To  Higby Road Cemetary Street Fairgrounds Distribution Center |
| 11.6 | West Main Street Ilion |
Frankfort | Main Street Begin two-lane undivided freeway |
| 12.7 |  Ilion |
To  |
|
| 14.2 |   SouthMohawk |
|
At-grade intersection |
| Speed Limit 55 | |||
| Herkimer County | |||