US 219 is the main corridor from Buffalo south to Salamanca and towards Pennsylvania. The route is a freeway, known as the Southern Expressway, from Buffalo to a stub with Peters Road south of Springville. Although the route is planned to be upgraded all the way south to I-86 near Salamanca, work is currently postponed infefinately. The local municipalities continue to push for renewed construction on the freeway, starting with the interchange with I-86.
| Mile | Northbound | Southbound | Notes |
|---|---|---|---|
| Cattaraugus County | |||
| Speed Limit 55 | |||
| 38.4 |  |
Peters Road All traffic must exit |
 SouthStub ramp |
| Speed Limit 65 | |||
| Erie County | Cattaraugus County | ||
| Speed Limit 55 | |||
| 41.9 |  Springville Gowanda |
Former end of freeway | |
| 45.0 | Genesee Road | ||
| 51.2 | Rice Road Colden |
||
| 56.0 |  Boston Hamburg |
||
| 60.1 | To  To  Armor Duells Road Chestnut Ridge Park |
||
| 61.2 |  Orchard Park |
||
| 63.0 |  EastMile Strip Road |
||
| 63.0 | West Mile Strip Road |
||
| Speed Limit 55 | Speed Limit 65 | ||
| 66.0 | Ridge Road East West Seneca |
||
| 66.0 | Ridge Road West Lackawanna |
||
| 66.5 |  East  EastBuffalo |
 |
|
| Speed Limit 55 | |||
| Erie County | |||